Endocrine Abstracts

Introduction: Omentin is a visceral fat tissue adipokine which regulates metabolism (insulin sensitivity) and presents an anti-inflammatory activities, by lowering C-reactive protein concentration, in obesity and diabetes mellitus type 2. Polycystic ovary syndrome is the most common endocrinopathy in women of childbearing age. One of the major disorders in the PCOS metabolic phenotype is obesity and hyperinsulinaemia. The anthropometric indicators are useful tools for carbohyd...

Adrenocortical carcinoma is an aggressive tumor of endocrine system with an annual incidence of 1–2 cases per million. The most significant prognostic factors are tumor size, disease stage at the time of putting the diagnosis and treatment method. Advanced age of the patient, and hormonal activity of the cancer are also related to poor prognosis.Materials and methods: In our study we collected data of 12 patients who were treated in Endocrinology Cl...

Objectives: Amino acids (AA) plasma profile is associated with cardiometabolic diseases (CMD), predicts diabetes mellitus type 2 (DM2) and cardiovascular diseases (CVD) many years in advance. Metabolic syndrome (MS) defines the area of metabolic disturbances that precede DM2 and CVD development. The primary objective of the study was to examine the association between BCAA (branched chain amino acids), AAA (aromatic amino acids) profile and MS’s phenotype and to evaluate ...

Hypersensitivity of hypothalamic–pituitary–adrenal (HPA) axis is considered to be an important factor in the pathogenesis of depression. Interestingly, glucagon-like peptide-1 (GLP-1) – an incretin hormone involved in the maintenance of glucose homeostasis in the periphery is known to activate HPA axis. The aim of the present study was to investigate whether prenatal stress (an animal model of depression) may influence levels of GLP-1 and GLP-1 receptor (GLP-1R)...

Introduction: Recently, the immune hypothesis of depression has gained a new dimension because of inflammasomes. NLRP3 inflammasome is a protein complex and its activation leads to stimulation of the enzyme caspase 1 responsible for generation of active form of pro-inflammatory cytokines: IL-1 β and IL-18. Recently postulated ‘inflammasome theory of depression’ assumes that depression is based on a disturbance of the mechanisms regulating NLRP3 complexes and unc...

POEMS syndrome characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes is a rare disease that usually presents in the 6th decade. We report a case of a young male in whom the presenting manifestations were mandibular mass, adrenal insufficiency and peripheral polyneuropathy. Clinical case: A thirty-three year old man from Guinea-Bissau was admitted to our hospital with asthenia, weight loss, decreased tactile sensibility with pain ...

Introduction: Calcium ions (Ca2+) play an essential role in process of correct β-cell insulin secretion. Hypocalcemia impairs insulin secretion leading to glucose metabolism disorders and insulin resistance.Case study: 62 -year old female patient with 18 years history of type 2 diabetes, treated with insulin, suspected of hypoparathyroidism, was admitted to the Department and Clinic of Endocrinology, Medical University of Lublin because o...

Introduction: Previous studies suggest close relationship between thyroid morphology and the danger of thyroid hormones (THs) disturbances after high single dose of iodine-containing contrast agent. The aim of the study was to assess the prognostic risk factors which influence on THs after the cardiac catheterization at patient with coronary artery disease (CAD).Methods: One hundred twenty patient (F/M=40/80, 59±11 years old) without recognized prev...

Introduction: The aim of the study was to asses frequency of the components of metabolic syndrome (MS) according to the criteria of the International Diabetes Federation (IDF) in patients with adrenal incidentaloma (AI) without hormonal activity.Design: The study comprised of patients with AI without hormonal activity, confirmed in CT. The adrenal function was determined by measuring circadian rhythm of cortisol and/or dexametasone suppression test, aldo...

Introduction: Left ventricular remodeling (LVR) is the most important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of free triiodothyronine (fT3) in the prediction of LVR after AMI and primary coronary angioplasty (PCI).Methods: Seventy patients (F/M=17/53, 61±11 years old) without recognized previous thyroid dysfunction and AMI were enrolled into the prospective observational study. Conventional and...